簡要描述:抑制劑BRD6688,CAS:1404562-17-9
BRD6688,CAS:1404562-17-9
BRD6688是一種HDAC抑制劑,其HDAC1,2和3的IC50分別為21 nM,100 nM和11.48μM[1]。與HDAC1相比,HDAC2具有優(yōu)先結(jié)合動力學,延長半衰期6倍(381 min 65分鐘).1 穿越血腦屏障,并已顯示在CK-p25神經(jīng)變性小鼠模型中在情境恐懼條件反射下拯救與p25誘導的神經(jīng)變性有關(guān)的記憶缺陷.
Formal Name
N-[2-amino-5-(4-pyridinyl)phenyl]-1-pyrrolidinecarboxamide
CAS Number
1404562-17-9
Molecular Formula
C16H18N4O
Formula Weight
282.3
Purity
≥98%
Formulation
A crystalline solid
λmax
315 nm
SMILES
O=C(N1CCCC1)NC2=CC(C3=CC=NC=C3)=CC=C2N
InChI Code
InChI=1S/C16H18N4O/c17-14-4-3-13(12-5-7-18-8-6-12)11-15(14)19-16(21)20-9-1-2-10-20/h3-8,11H,1-2,9-10,17H2,(H,19,21)
InChI Key
YZXBMJVMSBSGMM-UHFFFAOYSA-N
Warning - this product is not for human or veterinary use.
SHIPPING & STORAGE
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years